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Acta Médica Peruana

On-line version ISSN 1728-5917


AGUILAR-VILLANUEVA, Daniel Anderson et al. Effect of the ethanol extract of Tropaeolum majus (cress) upon Trichophyton mentagrophites-induced mycosis in Rattus norvegicus. Acta méd. Peru [online]. 2017, vol.34, n.3, pp.196-202. ISSN 1728-5917.

Objective: To determine the effect of the ethanol extract of Tropaeolum majus (cress) upon Trichophyton mentagrophites (TM) - induced tinea in Rattus norvegicus (RN). Materials and methods: This is an experimental randomized trial which included 21 male RN specimens, who were induced a superficial fungal infection; after the infection had developed, the animals were randomly divided in three 7-individual groups; Group I received placebo, Group II received an ointment prepared with a 0.4% ethanol extract of Tropaeolum majus (cress), and Group III received 1% terbinafine during 30 consecutive days, respectively. A clinical exam looking for signs and symptoms present in skin fungal infections was performed, using an arbitrary qualitative ordinal scale that was adapted for this trial. Also, laboratory exams were performed: direct examination of skin samples with 20% KOH, and dextrose-Sabouraud agar cultures in order to confirm the presence of superficial fungal infections before and after therapy. Results: Group II showed a significant reduction of clinical findings compared with Group I (p=0.001), while when compared with Group III, a positive clinical outcome was found in both groups (p=0.05). Conclusion: The ethanol extract of Tropaeolum majus (cress) has antifungal action upon TM-induced tinea in RN (p<0.05), and it may be considered as a safe option for the therapy of tinea

Keywords : Antifungal agents; Mycoses; Tropaeolum majus; Trichophyton.

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