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Print version ISSN 1815-8242On-line version ISSN 2413-3299


ALAYO MENDOZA, Wily Edgardo; FIESTAS JACINTO, Ramiro; AYALA JARA, Carmen Isolina  and  CASTILLO SAAVEDRA, Ericson Felix. Development of a cream of leaves of Piper aduncum L. (Piperaceae) with photoprotective activity in vitro. Arnaldoa [online]. 2018, vol.25, n.1, pp.115-126. ISSN 1815-8242.

The purpose of this work was to develop a cream based on the hydroalcoholic extract of Piper aduncum (Piperaceae) leaves and to evaluate its photoprotective activity in vitro. The first stage of the study began with the collection of leaves of Piper aduncum "matico" from the botanical garden of medicinal plants "Rosa Elena de los Rios Martinez" of the Faculty of Pharmacy and Biochemistry, National University of Trujillo, by the method of herborization . The preparation of the formulation began with obtaining the extract by the percolation method using ethanol solvent 70° GL and, then, the concentration was determined, for the subsequent design of the cream and the respective organoleptic and physicochemical controls. In the second stage, the in vitro photoprotective activity of the cream was determined by spectrophotometric method in the region of ultraviolet radiation type B (UVB) of 290-320 nm. Regarding the results, a concentration of 48.6 mg of dry extract/mL was obtained, the developed O/A cream had a homogeneous appearance, with a sun protection factor (SPF) of 2.29. It is concluded that the sunscreen cream developed from the hydroalcoholic extract of leaves of Piper aduncum has a low level of photoprotection according to the classification of international organisms.

Keywords : Piper aduncum; sun protection factor; extract, cream.

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