SciELO - Scientific Electronic Library Online

vol.25 issue2Effect of Bacteria Native from Cultivated and Pristine Soil on the Control of Root Knot Nematode, Meloidogyne Javanica, Under in Vitro Conditions and Biomass ProductionHypoglycemic Activity of the Extracts of Smallanthus Sonchifolius "Yacon" and Vitis Vinifera "Grape" in Rats with Diabetes Induced by Alloxan author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




  • Have no cited articlesCited by SciELO

Related links



Print version ISSN 1815-8242On-line version ISSN 2413-3299


LUJAN DOMINGUEZ, María Elena et al. Development of a gel of Vaccinium corymbosum L. (Ericaceae) fruits with regenerative activity of dermal tissue. Arnaldoa [online]. 2018, vol.25, n.2, pp.529-538. ISSN 1815-8242.

The purpose of the study was to develop a gel of fruit of Vaccinium corymbosum L. (Ericaceae) with regenerative activity of dermal tissue. The gel formulation began with the preparation of the concentrate, which was made from a mixture of ethanol and citric acid at 1%, raw material/solvent ratio 1:3 kg/kg, temperature 36 ± 1 °C, extraction time 2 hours, and then concentrated in rotary evaporator. Subsequently, excipients widely used for this pharmaceutical form were added to the concentrate of Vaccinium corymbosum 10%. The contrast design was carried out with 24 Lewis albino strain male rats distributed in three contrast groups: control, gel of Vaccinium corymbosum 10% concentrate (problem) and Cicatricure® (standard). The results evaluated the evolution of healing in the injured area from 0 to 21 days (macroscopic level), and in the histological study of cicatrization (microscopic level). It is concluded that the gel of the concentrate of Vaccinium corymbosum 10% presented better regenerative capacity of dermal tissue after 7 days of treatment, and increased the promotion of the processes of epithelization, neovascularization, and proliferation of fibroblasts and collagen.

Keywords : Vaccinium corymbosum L; gel; regeneration; dermal tissue.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )